Selection of an optimal method for sterilization of the medical grade biodegradable polymers

Alexander G. Samokhin, Vadim O. Tkachenko, Vasily A. Kuznetsov, Ekaterina O. Zemlyakova, Denis V. Nesterov, Petr M. Larionov, Alexander V. Pestov

Результат исследования: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаярецензирование

1 Цитирования (Scopus)

Аннотация

Aim of this study was to assess possible influence of chitosan-based gels (without cross-linker treatment and cross-linked with one of the next substances - glutaraldehyde, hexamethylene diisocyanate or oxidized alginate) onto live tissues in in vivo animal model and evaluate and select optimal sterilization method of such biodegradable materials. Sterilization of all chitosan gel samples were performed using three different methods: steam sterilization, low-temperature hydrogen peroxide plasma and radiation sterilization. The best swelling degree values were obtained for chitosan gels cross-linked with glutaraldehyde or hexamethylene diisocyanate. Further in vivo animal model 14-day evaluation showed no toxic, immunosuppression or sensitization effects nor dystrophic and autoimmune changes in live tissues that have been directed in contact with implanted polymer. Among all three evaluated sterilization methods the best one was the radiation sterilization in terms of preserving the desired characteristics of swelling and minimal changes in chemical composition and properties of sterilized materials, even with 25 kGy absorbed dose that allows sterility assurance level at 10-6 to be achieved.

Язык оригиналаанглийский
Название основной публикацииModern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2018
Подзаголовок основной публикацииProceedings of the II International
РедакторыSougata Santra, Grigory V. Zyryanov, Leila K. Sadieva
ИздательAmerican Institute of Physics Inc.
Том2063
ISBN (электронное издание)9780735417915
DOI
СостояниеОпубликовано - 11 янв 2019
Событие2nd International conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2018 - Yekaterinburg, Российская Федерация
Продолжительность: 15 ноя 201817 ноя 2018

Конференция

Конференция2nd International conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2018
СтранаРоссийская Федерация
ГородYekaterinburg
Период15.11.201817.11.2018

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  • Цитировать

    Samokhin, A. G., Tkachenko, V. O., Kuznetsov, V. A., Zemlyakova, E. O., Nesterov, D. V., Larionov, P. M., & Pestov, A. V. (2019). Selection of an optimal method for sterilization of the medical grade biodegradable polymers. В S. Santra, G. V. Zyryanov, & L. K. Sadieva (Ред.), Modern Synthetic Methodologies for Creating Drugs and Functional Materials, MOSM 2018: Proceedings of the II International (Том 2063). [030017] American Institute of Physics Inc.. https://doi.org/10.1063/1.5087325