Screening and characterization of cocrystal formation between betulin and terephthalic acid

Anastasiya V. Mikhailovskaya, Svetlana A. Myz, Natalia V. Bulina, Konstantin B. Gerasimov, Svetlana A. Kuznetsova, Tatyana P. Shakhtshneider

Результат исследования: Научные публикации в периодических изданияхстатья по материалам конференциирецензирование

1 Цитирования (Scopus)

Аннотация

The pharmaceutical cocrystals are nowdays intensively studied due to the improvements of solubility, stability, processability, etc. of the drugs. In this work, the cocrystals of betulin with terephthalic acid as a coformer were prepared by liquid-assisted grinding method. The formation of cocrystals was confirmed by powder X-ray diffraction, IR spectroscopy and thermal analysis methods. HPLC analysis showed that in the case of betulin - terephthalic acid cocrystals, solubility of betulin was significantly improved compared to the initial betulin as well as betulin from cocrystals with aliphatic dicarboxylic acids which were earlier prepared.

Язык оригиналаанглийский
Страницы (с-по)381-383
Число страниц3
ЖурналMaterials Today: Proceedings
Том25
DOI
СостояниеОпубликовано - 2019
Событие3rd All-Russian Conference, with International Participation Hot Topics of Solid State Chemistry : From New Ideas to New Materials, HTSSC 2019 - Novosibirsk, Российская Федерация
Продолжительность: 1 окт 20195 окт 2019

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