TY - JOUR
T1 - Role of YB-1 in Regulation of Poly(ADP-Ribosylation) Catalyzed by Poly(ADP-Ribose) Polymerases
AU - Alemasova, Elizaveta E.
AU - Naumenko, Konstantin N.
AU - Sukhanova, Maria V.
AU - Lavrik, Olga I.
N1 - Funding Information:
The work was supported by the Russian Science Foundation (projects no. 19-14-00107 and no. 20-14-00086).
Publisher Copyright:
© 2022, Pleiades Publishing, Ltd.
PY - 2022/1
Y1 - 2022/1
N2 - Poly(ADP-ribosyl)ation is a post-translational modification of proteins that performs an essential regulatory function in the cellular response to DNA damage. The key enzyme synthesizing poly(ADP-ribose) (PAR) in the cells is poly(ADP-ribose) polymerase 1 (PARP1). Understanding the mechanisms of the PARP1 activity regulation within the cells is necessary for development of the PARP1-targeted antitumor therapy. This review is devoted to the studies of the role of the RNA-binding protein YB-1 in the PARP1-catalyzed PARylation. The mechanisms of PARP1 activity stimulation by YB-1 protein can possibly be extended to other RNA-binding proteins involved in the maintenance of the genome stability.
AB - Poly(ADP-ribosyl)ation is a post-translational modification of proteins that performs an essential regulatory function in the cellular response to DNA damage. The key enzyme synthesizing poly(ADP-ribose) (PAR) in the cells is poly(ADP-ribose) polymerase 1 (PARP1). Understanding the mechanisms of the PARP1 activity regulation within the cells is necessary for development of the PARP1-targeted antitumor therapy. This review is devoted to the studies of the role of the RNA-binding protein YB-1 in the PARP1-catalyzed PARylation. The mechanisms of PARP1 activity stimulation by YB-1 protein can possibly be extended to other RNA-binding proteins involved in the maintenance of the genome stability.
KW - poly(ADP-ribose) (PAR)
KW - poly(ADP-ribose) polymerase 1 (PARP1)
KW - poly(ADP-ribosyl)ation (PARylation)
KW - RNA-binding protein (RBP)
KW - Y-box-binding protein 1 (YB-1)
KW - Poly ADP Ribosylation
KW - Proteins/metabolism
KW - Poly(ADP-ribose) Polymerases/metabolism
KW - Catalysis
KW - DNA Damage
KW - Poly Adenosine Diphosphate Ribose
UR - http://www.scopus.com/inward/record.url?scp=85124032535&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/97f9a842-2210-3c8e-9baf-9d4dd94717e8/
U2 - 10.1134/S0006297922140048
DO - 10.1134/S0006297922140048
M3 - Review article
C2 - 35501985
AN - SCOPUS:85124032535
VL - 87
SP - S32-S47
JO - Biochemistry (Moscow)
JF - Biochemistry (Moscow)
SN - 0006-2979
IS - Suppl 1
ER -