Role of YB-1 in Regulation of Poly(ADP-Ribosylation) Catalyzed by Poly(ADP-Ribose) Polymerases

Elizaveta E. Alemasova, Konstantin N. Naumenko, Maria V. Sukhanova, Olga I. Lavrik

Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование

Аннотация

Poly(ADP-ribosyl)ation is a post-translational modification of proteins that performs an essential regulatory function in the cellular response to DNA damage. The key enzyme synthesizing poly(ADP-ribose) (PAR) in the cells is poly(ADP-ribose) polymerase 1 (PARP1). Understanding the mechanisms of the PARP1 activity regulation within the cells is necessary for development of the PARP1-targeted antitumor therapy. This review is devoted to the studies of the role of the RNA-binding protein YB-1 in the PARP1-catalyzed PARylation. The mechanisms of PARP1 activity stimulation by YB-1 protein can possibly be extended to other RNA-binding proteins involved in the maintenance of the genome stability.

Язык оригиналаанглийский
Страницы (с-по)S32-S47
ЖурналBiochemistry (Moscow)
Том87
Номер выпускаSuppl 1
DOI
СостояниеОпубликовано - янв. 2022

Предметные области OECD FOS+WOS

  • 1.06.CQ БИОХИМИЯ И МОЛЕКУЛЯРНАЯ БИОЛОГИЯ
  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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