The role of exosomal tetraspanins and proteases in tumor progression

Переведенное название: Rol' tetraspaninov i proteaz ékzosom v opukholevoĭ progressii

N. V. Yunusova, E. A. Tugutova, S. N. Tamkovich, I. V. Kondakova

Результат исследования: Научные публикации в периодических изданияхобзорная статья

1 Цитирования (Scopus)

Аннотация

Major (CD9, CD63, CD81) and others (CD82, CD151, Tspan8) tetraspanins are widely represented in exosomes, where they interact with various proteins and form functional tetraspanin complexes. Tetraspanin complexes include proteases. Tetraspanin-associated exosomal proteases (ADAM proteases, MMPs, EMMPRIN) play an important role in the processes of cell motility, migration, invasion and formation of metastases. Also, a significant contribution to tumor progression is made by proteases that are not associated with tetraspanins. They destabilize intercellular contacts, promote migration and invasion of tumor cells, participate in the regulation of the expression IGF-I, VEGF and transcription factors activation/deactivation. The role of other proteases of exosomes in the processes of tumor progression is being clarified.

Переведенное названиеRol' tetraspaninov i proteaz ékzosom v opukholevoĭ progressii
Язык оригиналаанглийский
Страницы (с-по)123-133
Число страниц11
ЖурналBiomeditsinskaya Khimiya
Том64
Номер выпуска2
DOI
СостояниеОпубликовано - мар 2018

Ключевые слова

  • Cell Movement
  • Disease Progression
  • Exosomes
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasms/enzymology
  • Peptide Hydrolases/physiology
  • Tetraspanins/physiology

Fingerprint Подробные сведения о темах исследования «Rol' tetraspaninov i proteaz ékzosom v opukholevoĭ progressii». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать