Reticulons: Classification, structure and functional dynamics in cell membranes

Reticulons are a proteins superfamily, so-called because of their predominant intracellular localization in the endoplasmic reticulum. Their main function is to maintain a form of the membrane-limited intracellular organelles (especially endoplasmic reticulum). This review is devoted to the classification, structure and function of reticulons. A detailed analysis of the literature data on the entire reticulon family is provided, special emphasis is placed on mammalian reticulons. This review summarizes currently available information on reticulons.