Regulatory SNPs and their widespread effects on the transcriptome

Vasily M. Merkulov, Elena Yu Leberfarb, Tatiana I. Merkulova

Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование

6 Цитирования (Scopus)


Currently, it is generally accepted that the cis-acting effects of noncoding variants on gene expression are a major factor for phenotypic variation in complex traits and disease susceptibility. Meanwhile, the protein products of many target genes for the identified cis-regulatory variants (rSNPs) are regulatory molecules themselves (transcription factors, effectors, components of signal transduction pathways, etc.), which implies dramatic downstream effects of these variations on complex gene networks. Here, we brief the results of recent most comprehensive studies on the role of rSNPs in transcriptional regulation across the genome.

Язык оригиналаанглийский
Страницы (с-по)1069-1075
Число страниц7
ЖурналJournal of Biosciences
Номер выпуска5
СостояниеОпубликовано - 1 дек 2018


Подробные сведения о темах исследования «Regulatory SNPs and their widespread effects on the transcriptome». Вместе они формируют уникальный семантический отпечаток (fingerprint).