Purposeful regioselectivity control of the Birch reductive alkylation of biphenyl-4-carbonitrile

Pavel A. Fedyushin, Roman Yu Peshkov, Elena V. Panteleeva, Evgeny V. Tretyakov, Irina V. Beregovaya, Yuri V. Gatilov, Vitalij D. Shteingarts

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

Birch's reductive alkylation of biphenyl-4-carbonitrile (1) provides alkylated 1,4-dihydroderivatives of various structural types: 4-alkyl-4-phenylcyclohexa-2,5-dienone, 1,4-dialkyl-4-phenylcyclohexa-2,5-dienecarbonitrile (with the same or different alkyl fragments), and 4-(1-alkylcyclohexa-2,5-dienyl)benzonitrile. Each of these products become dominant depending on the nature of long-living anionic form generated from 1, namely, the stable product of two-electrons reduction - dianion (1 2- ); 1-alkyl-4-cyano-1-phenylcyclohexa-2,5-dien-4-yl anion (1-Alk 1 - ), originated due to the alkylation of dianion 1 2- at the position 1 of biphenyl moiety; or 1-(4-cyanophenyl)cyclohexa-2,5-dien-1-yl anion (1-H 4' - ), being the product of dianion 1 2- protonation at position 4' by protonating reagent (MeOH or NH4Cl). The orientation of alkyl fragment incorporation into biphenyl-4-carbonitrile scaffold is in agreement with calculated electronic structure of the anionic species under investigation. The dominating type of their reactivity towards alkyl halides proved to be nucleophilic (S N 2 mechanism).

Язык оригиналаанглийский
Страницы (с-по)842-851
Число страниц10
ЖурналTetrahedron
Том74
Номер выпуска8
DOI
СостояниеОпубликовано - 22 фев 2018

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