Preparation and characterization of a glycyrrhizic acid-based drug delivery system for allergen-specific immunotherapy

Ekaterina Pashkina, Veronika Evseenko, Natalya Dumchenko, Maxim Zelikman, Alina Aktanova, Maria Bykova, Mikhail Khvostov, Aleksandr Dushkin, Vladimir Kozlov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. It is also known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, meaning that it could potentially enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects. Thus, the study of the immunomodulatory effect of the supramolecular complexes (micelles) of GA with extracts of allergens holds promise for the development of new drugs for AIT.

Язык оригиналаанглийский
Номер статьи148
ЖурналNanomaterials
Том12
Номер выпуска1
DOI
СостояниеОпубликовано - 1 янв 2022

Предметные области OECD FOS+WOS

  • 2.05 ТЕХНОЛОГИЯ МАТЕРИАЛОВ
  • 2.04 ХИМИЧЕСКИЕ ТЕХНОЛОГИИ
  • 2.1.NS НАНОНАУКА И НАНОТЕХНОЛОГИИ
  • 2.05.PM МАТЕРИАЛОВЕДЕНИЕ, МУЛЬТИДИСЦИПЛИНАРНОЕ
  • 1.03.UB ФИЗИКА, ПРИКЛАДНАЯ
  • 1.04.DY ХИМИЯ, МУЛЬТИДИСЦИПЛИНАРНАЯ

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