Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair

N. I. Rechkunova, E. A. Maltseva, O. I. Lavrik

Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование

7 Цитирования (Scopus)


Nucleotide excision repair (NER) is one of the major DNA repair pathways aimed at maintaining genome stability. Correction of DNA damage by the NER system is a multistage process that proceeds with the formation of multiple DNA-protein and protein-protein intermediate complexes and requires precise coordination and regulation. NER proteins undergo post-translational modifications, such as ubiquitination, sumoylation, phosphorylation, acetylation, and poly(ADP-ribosyl)ation. These modifications affect the interaction of NER factors with DNA and other proteins and thus regulate either their recruitment into the complexes or dissociation from these complexes at certain stages of DNA repair, as well as modulate the functional activity of NER proteins and control the process of DNA repair in general. Here, we review the data on the post-translational modifications of NER factors and their effects on DNA repair. Protein poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerase 1 and its impact on NER are discussed in detail, since such analysis has not been done before.

Язык оригиналаанглийский
Страницы (с-по)1008-1020
Число страниц13
ЖурналBiochemistry (Moscow)
Номер выпуска9
СостояниеОпубликовано - 1 сен 2019


Подробные сведения о темах исследования «Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair». Вместе они формируют уникальный семантический отпечаток (fingerprint).