Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions

Elizaveta E. Alemasova, Olga I. Lavrik

Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование

Аннотация

Biomolecular condensates are nonmembrane cellular compartments whose formation in many cases involves phase separation (PS). Despite much research interest in this mechanism of macromolecular self-organization, the concept of PS as applied to a live cell faces certain challenges. In this review, we discuss a basic model of PS and the role of site-specific interactions and percolation in cellular PS-related events. Using a multivalent poly(ADP-ribose) molecule as an example, which has high PS-driving potential due to its structural features, we consider how site-specific interactions and network formation are involved in the formation of phase-separated cellular condensates.

Язык оригиналаанглийский
Номер статьи14075
ЖурналInternational Journal of Molecular Sciences
Том23
Номер выпуска22
DOI
СостояниеОпубликовано - нояб. 2022

Предметные области OECD FOS+WOS

  • 2.04 ХИМИЧЕСКИЕ ТЕХНОЛОГИИ
  • 1.04 ХИМИЧЕСКИЕ НАУКИ
  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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