Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt

E. S. Meteleva, Yu S. Chistyachenko, L. P. Suntsova, M. A. Tsyganov, G. B. Vishnivetskaya, D. F. Avgustinovich, M. V. Khvostov, N. E. Polyakov, T. G. Tolstikova, V. A. Mordvinov, A. V. Dushkin, N. Z. Lyakhov

Результат исследования: Научные публикации в периодических изданияхстатья

10 Цитирования (Scopus)

Аннотация

The mechanochemical preparation of solid compositions of praziquantel with plant saponin (glycyrrhizic acid disodium salt) is described. The study of a number of physicochemical parameters showed that dissolving solid compositions in water is accompanied by the inclusion of praziquantel molecules into micelles, which are formed in the solution of the glycyrrhizic acid disodium salt. Using the opisthorchiasis model caused by Opisthorchis felineus, we found a 4- to 11-fold increase in the anthelmintic activity of praziquantel in the composition as compared to the official praziquantel. According to the pharmacokinetic data, the use of the composition increased the bioavailability of praziquantel 3 times.

Язык оригиналаанглийский
Страницы (с-по)228-231
Число страниц4
ЖурналDoklady Biochemistry and Biophysics
Том481
Номер выпуска1
DOI
СостояниеОпубликовано - 1 июл 2018

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  • Цитировать

    Meteleva, E. S., Chistyachenko, Y. S., Suntsova, L. P., Tsyganov, M. A., Vishnivetskaya, G. B., Avgustinovich, D. F., Khvostov, M. V., Polyakov, N. E., Tolstikova, T. G., Mordvinov, V. A., Dushkin, A. V., & Lyakhov, N. Z. (2018). Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt. Doklady Biochemistry and Biophysics, 481(1), 228-231. https://doi.org/10.1134/S1607672918040142