Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity

Elvira E. Shults, Makhmut M. Shakirov, Mikhail A. Pokrovsky, Tatijana N. Petrova, Andrey G. Pokrovsky, Petr G. Gorovoy

    Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

    16 Цитирования (Scopus)

    Аннотация

    Twenty-one phenolic compounds (1–21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19) and 6″-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract. Compounds 2–4, 10, 11, 19 and 21 were evaluated for their cytotoxic activity with respect to model cancer cell lines (CEM-13, MT-4, U-937) using the conventional MTT assays. Isoflavonoid calycosin (4) showed the best potency against human T-cell leukaemia cells MT-4 (CTD50, 2.9 μM). Pterocarpans medicarpin (10) and homopterocarpin (11) exhibit anticancer activity in micromolar range with selectivity on the human monocyte cells U-937. The isoflavan (3R)-vestitol (16) was highly selective on the lymphoblastoid leukaemia cells CEM-13 and was more active than the drug doxorubicin

    Язык оригиналаанглийский
    Страницы (с-по)445-452
    Число страниц8
    ЖурналNatural Product Research
    Том31
    Номер выпуска4
    DOI
    СостояниеОпубликовано - фев 2017

    Fingerprint

    Подробные сведения о темах исследования «Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity». Вместе они формируют уникальный семантический отпечаток (fingerprint).

    Цитировать