Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity

Elvira E. Shults, Makhmut M. Shakirov, Mikhail A. Pokrovsky, Tatijana N. Petrova, Andrey G. Pokrovsky, Petr G. Gorovoy

Результат исследования: Научные публикации в периодических изданияхстатья

13 Цитирования (Scopus)

Аннотация

Twenty-one phenolic compounds (1–21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19) and 6″-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract. Compounds 2–4, 10, 11, 19 and 21 were evaluated for their cytotoxic activity with respect to model cancer cell lines (CEM-13, MT-4, U-937) using the conventional MTT assays. Isoflavonoid calycosin (4) showed the best potency against human T-cell leukaemia cells MT-4 (CTD50, 2.9 μM). Pterocarpans medicarpin (10) and homopterocarpin (11) exhibit anticancer activity in micromolar range with selectivity on the human monocyte cells U-937. The isoflavan (3R)-vestitol (16) was highly selective on the lymphoblastoid leukaemia cells CEM-13 and was more active than the drug doxorubicin

Язык оригиналаанглийский
Страницы (с-по)445-452
Число страниц8
ЖурналNatural Product Research
Том31
Номер выпуска4
DOI
СостояниеОпубликовано - фев 2017

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