Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery

Evgeny Apartsin; Nadezhda Knauer; Valeria Arkhipova; Ekaterina Pashkina; Alina Aktanova; Julia Poletaeva; Javier Sánchez-Nieves; Francisco Javier de la Mata; Rafael Gómez

doi:10.3390/nano10101899

Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery

Evgeny Apartsin, Nadezhda Knauer, Valeria Arkhipova, Ekaterina Pashkina, Alina Aktanova, Julia Poletaeva, Javier Sánchez-Nieves, Francisco Javier de la Mata, Rafael Gómez

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

1 Цитирования (Scopus)

Аннотация

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Язык оригинала	английский
Номер статьи	1899
Страницы (с-по)	1-15
Число страниц	15
Журнал	Nanomaterials
Том	10
Номер выпуска	10
DOI	https://doi.org/10.3390/nano10101899
Состояние	Опубликовано - 1 окт 2020

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10.3390/nano10101899

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title = "Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery",

abstract = "Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.",

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Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery. / Apartsin, Evgeny; Knauer, Nadezhda; Arkhipova, Valeria; Pashkina, Ekaterina; Aktanova, Alina; Poletaeva, Julia; Sánchez-Nieves, Javier; de la Mata, Francisco Javier; Gómez, Rafael.

В: Nanomaterials, Том 10, № 10, 1899, 01.10.2020, стр. 1-15.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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T1 - Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery

AU - Apartsin, Evgeny

AU - Knauer, Nadezhda

AU - Arkhipova, Valeria

AU - Pashkina, Ekaterina

AU - Aktanova, Alina

AU - Poletaeva, Julia

AU - Sánchez-Nieves, Javier

AU - de la Mata, Francisco Javier

AU - Gómez, Rafael

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N2 - Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

AB - Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

KW - Amphiphile

KW - Carbosilane

KW - Dendron

KW - Doxorubicin

KW - Leukaemia

KW - Methotrexate

KW - PH-sensitive

KW - Self-assembly

KW - Triazine

KW - Vesicles

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