Аннотация
Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.
Язык оригинала | английский |
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Номер статьи | 1899 |
Страницы (с-по) | 1-15 |
Число страниц | 15 |
Журнал | Nanomaterials |
Том | 10 |
Номер выпуска | 10 |
DOI | |
Состояние | Опубликовано - 1 окт 2020 |
Предметные области OECD FOS+WOS
- 2.1.NS НАНОНАУКА И НАНОТЕХНОЛОГИИ
- 2.05.PM МАТЕРИАЛОВЕДЕНИЕ, МУЛЬТИДИСЦИПЛИНАРНОЕ
- 1.03.UB ФИЗИКА, ПРИКЛАДНАЯ
- 1.04.DY ХИМИЯ, МУЛЬТИДИСЦИПЛИНАРНАЯ