Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery

Evgeny Apartsin, Nadezhda Knauer, Valeria Arkhipova, Ekaterina Pashkina, Alina Aktanova, Julia Poletaeva, Javier Sánchez-Nieves, Francisco Javier de la Mata, Rafael Gómez

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Язык оригиналаанглийский
Номер статьи1899
Страницы (с-по)1-15
Число страниц15
ЖурналNanomaterials
Том10
Номер выпуска10
DOI
СостояниеОпубликовано - 1 окт 2020

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