Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast

A. I. Autenshlyus; A. V. Golovanova; A. A. Studenikina; I. I. Brusentsov; A. V. Proskura; I. P. Zhurakovskiy; S. A. Arkhipov; S. V. Sidorov; V. A. Vavilin; V. V. Lyakhovich

doi:10.1134/S1607672919010162

Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast

A. I. Autenshlyus, A. V. Golovanova, A. A. Studenikina, I. I. Brusentsov, A. V. Proskura, I. P. Zhurakovskiy, S. A. Arkhipov, S. V. Sidorov, V. A. Vavilin, V. V. Lyakhovich

Кафедра хирургических болезней ИМПЗ

Результат исследования: Научные публикации в периодических изданиях › статья

4 Цитирования (Scopus)

Аннотация

Abstract: Biopsy material of patients with malignant and benign breast diseases was examined. HRG mRNA expression was detected in 70% of cases in biopsy material obtained from patients with nonspecific invasive carcinoma and in 66.7% of cases in biopsy material of patients with benign breast diseases. Immunohistochemical analysis revealed expression of collagen II, the beta-1 integrin, and E-cadherin—markers of epithelial–mesenchymal transition. The use of RT-qPCR combined with immunohistochemical study made it possible to identify atypical cells, which can be regarded as precancerous changes, in individual patients.

Язык оригинала	английский
Страницы (с-по)	59-62
Число страниц	4
Журнал	Doklady Biochemistry and Biophysics
Том	484
Номер выпуска	1
DOI	https://doi.org/10.1134/S1607672919010162
Состояние	Опубликовано - 1 мая 2019

Доступ к документу

10.1134/S1607672919010162

Link to publication in Scopus

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Цитировать

Autenshlyus, A. I., Golovanova, A. V., Studenikina, A. A., Brusentsov, I. I., Proskura, A. V., Zhurakovskiy, I. P., Arkhipov, S. A., Sidorov, S. V., Vavilin, V. A., & Lyakhovich, V. V. (2019). Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast. Doklady Biochemistry and Biophysics, 484(1), 59-62. https://doi.org/10.1134/S1607672919010162

Autenshlyus, A. I. ; Golovanova, A. V. ; Studenikina, A. A. ; Brusentsov, I. I. ; Proskura, A. V. ; Zhurakovskiy, I. P. ; Arkhipov, S. A. ; Sidorov, S. V. ; Vavilin, V. A. ; Lyakhovich, V. V. / Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast. В: Doklady Biochemistry and Biophysics. 2019 ; Том 484, № 1. стр. 59-62.

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title = "Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast",

abstract = "Abstract: Biopsy material of patients with malignant and benign breast diseases was examined. HRG mRNA expression was detected in 70% of cases in biopsy material obtained from patients with nonspecific invasive carcinoma and in 66.7% of cases in biopsy material of patients with benign breast diseases. Immunohistochemical analysis revealed expression of collagen II, the beta-1 integrin, and E-cadherin—markers of epithelial–mesenchymal transition. The use of RT-qPCR combined with immunohistochemical study made it possible to identify atypical cells, which can be regarded as precancerous changes, in individual patients.",

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author = "Autenshlyus, {A. I.} and Golovanova, {A. V.} and Studenikina, {A. A.} and Brusentsov, {I. I.} and Proskura, {A. V.} and Zhurakovskiy, {I. P.} and Arkhipov, {S. A.} and Sidorov, {S. V.} and Vavilin, {V. A.} and Lyakhovich, {V. V.}",

year = "2019",

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doi = "10.1134/S1607672919010162",

language = "English",

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Autenshlyus, AI, Golovanova, AV, Studenikina, AA, Brusentsov, II, Proskura, AV, Zhurakovskiy, IP, Arkhipov, SA, Sidorov, SV, Vavilin, VA & Lyakhovich, VV 2019, 'Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast', Doklady Biochemistry and Biophysics, том. 484, № 1, стр. 59-62. https://doi.org/10.1134/S1607672919010162

Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast. / Autenshlyus, A. I.; Golovanova, A. V.; Studenikina, A. A.; Brusentsov, I. I.; Proskura, A. V.; Zhurakovskiy, I. P.; Arkhipov, S. A.; Sidorov, S. V.; Vavilin, V. A.; Lyakhovich, V. V.

В: Doklady Biochemistry and Biophysics, Том 484, № 1, 01.05.2019, стр. 59-62.

Результат исследования: Научные публикации в периодических изданиях › статья

TY - JOUR

T1 - Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast

AU - Autenshlyus, A. I.

AU - Golovanova, A. V.

AU - Studenikina, A. A.

AU - Brusentsov, I. I.

AU - Proskura, A. V.

AU - Zhurakovskiy, I. P.

AU - Arkhipov, S. A.

AU - Sidorov, S. V.

AU - Vavilin, V. A.

AU - Lyakhovich, V. V.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Abstract: Biopsy material of patients with malignant and benign breast diseases was examined. HRG mRNA expression was detected in 70% of cases in biopsy material obtained from patients with nonspecific invasive carcinoma and in 66.7% of cases in biopsy material of patients with benign breast diseases. Immunohistochemical analysis revealed expression of collagen II, the beta-1 integrin, and E-cadherin—markers of epithelial–mesenchymal transition. The use of RT-qPCR combined with immunohistochemical study made it possible to identify atypical cells, which can be regarded as precancerous changes, in individual patients.

AB - Abstract: Biopsy material of patients with malignant and benign breast diseases was examined. HRG mRNA expression was detected in 70% of cases in biopsy material obtained from patients with nonspecific invasive carcinoma and in 66.7% of cases in biopsy material of patients with benign breast diseases. Immunohistochemical analysis revealed expression of collagen II, the beta-1 integrin, and E-cadherin—markers of epithelial–mesenchymal transition. The use of RT-qPCR combined with immunohistochemical study made it possible to identify atypical cells, which can be regarded as precancerous changes, in individual patients.

KW - EPITHELIAL-MESENCHYMAL TRANSITION

KW - CANCER

KW - Cadherins/biosynthesis

KW - Humans

KW - Middle Aged

KW - Gene Expression Regulation, Neoplastic

KW - Proteins/genetics

KW - Antigens, CD/biosynthesis

KW - Neoplasm Proteins/biosynthesis

KW - Adolescent

KW - Epithelial-Mesenchymal Transition

KW - Adult

KW - Female

KW - Aged

KW - Breast Neoplasms/genetics

KW - Biomarkers, Tumor/biosynthesis

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U2 - 10.1134/S1607672919010162

DO - 10.1134/S1607672919010162

M3 - Article

C2 - 31012015

AN - SCOPUS:85064830947

VL - 484

SP - 59

EP - 62

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

ER -