Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast

A. I. Autenshlyus, A. V. Golovanova, A. A. Studenikina, I. I. Brusentsov, A. V. Proskura, I. P. Zhurakovskiy, S. A. Arkhipov, S. V. Sidorov, V. A. Vavilin, V. V. Lyakhovich

Результат исследования: Научные публикации в периодических изданияхстатья


Abstract: Biopsy material of patients with malignant and benign breast diseases was examined. HRG mRNA expression was detected in 70% of cases in biopsy material obtained from patients with nonspecific invasive carcinoma and in 66.7% of cases in biopsy material of patients with benign breast diseases. Immunohistochemical analysis revealed expression of collagen II, the beta-1 integrin, and E-cadherin—markers of epithelial–mesenchymal transition. The use of RT-qPCR combined with immunohistochemical study made it possible to identify atypical cells, which can be regarded as precancerous changes, in individual patients.

Язык оригиналаанглийский
Страницы (с-по)59-62
Число страниц4
ЖурналDoklady Biochemistry and Biophysics
Номер выпуска1
СостояниеОпубликовано - 1 мая 2019