@article{d145fbaca11d4a63b69ed7ff02c95289,
title = "Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast",
abstract = "Abstract: Biopsy material of patients with malignant and benign breast diseases was examined. HRG mRNA expression was detected in 70% of cases in biopsy material obtained from patients with nonspecific invasive carcinoma and in 66.7% of cases in biopsy material of patients with benign breast diseases. Immunohistochemical analysis revealed expression of collagen II, the beta-1 integrin, and E-cadherin—markers of epithelial–mesenchymal transition. The use of RT-qPCR combined with immunohistochemical study made it possible to identify atypical cells, which can be regarded as precancerous changes, in individual patients.",
keywords = "EPITHELIAL-MESENCHYMAL TRANSITION, CANCER, Cadherins/biosynthesis, Humans, Middle Aged, Gene Expression Regulation, Neoplastic, Proteins/genetics, Antigens, CD/biosynthesis, Neoplasm Proteins/biosynthesis, Adolescent, Epithelial-Mesenchymal Transition, Adult, Female, Aged, Breast Neoplasms/genetics, Biomarkers, Tumor/biosynthesis",
author = "Autenshlyus, {A. I.} and Golovanova, {A. V.} and Studenikina, {A. A.} and Brusentsov, {I. I.} and Proskura, {A. V.} and Zhurakovskiy, {I. P.} and Arkhipov, {S. A.} and Sidorov, {S. V.} and Vavilin, {V. A.} and Lyakhovich, {V. V.}",
year = "2019",
month = may,
day = "1",
doi = "10.1134/S1607672919010162",
language = "English",
volume = "484",
pages = "59--62",
journal = "Doklady Biochemistry and Biophysics",
issn = "1607-6729",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "1",
}