Parahydrogen-Induced Polarization of Amino Acids

Andrey N. Pravdivtsev, Gerd Buntkowsky, Simon B. Duckett, Igor V. Koptyug, Jan Bernd Hövener

Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование

1 Цитирования (Scopus)

Аннотация

Nuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spin has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid-state NMR and metabolic imaging in vivo). Parahydrogen (pH2) offers a fast and cost-efficient way to achieve hyperpolarization, and the last decade has seen extensive advances, including the synthesis of new tracers, catalysts, and transfer methods. The portfolio of hyperpolarized molecules now includes amino acids, which are of great interest for many applications. Here, we provide an overview of the current literature and developments in the hyperpolarization of amino acids and peptides.

Язык оригиналаанглийский
ЖурналAngewandte Chemie - International Edition
Ранняя дата в режиме онлайн26 фев 2021
DOI
СостояниеЭлектронная публикация перед печатью - 26 фев 2021

Предметные области OECD FOS+WOS

  • 2.04 ХИМИЧЕСКИЕ ТЕХНОЛОГИИ
  • 1.04 ХИМИЧЕСКИЕ НАУКИ

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