Parahydrogen-Induced Polarization of 1-13C-Acetates and 1-13C-Pyruvates Using Sidearm Hydrogenation of Vinyl, Allyl, and Propargyl Esters

Oleg G. Salnikov, Nikita V. Chukanov, Roman V. Shchepin, Isaac V. Manzanera Esteve, Kirill V. Kovtunov, Igor V. Koptyug, Eduard Y. Chekmenev

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

16 Цитирования (Scopus)


13C-hyperpolarized carboxylates, such as pyruvate and acetate, are emerging molecular contrast agents for magnetic resonance imaging (MRI) visualization of various diseases, including cancer. Here, we present a systematic study of 1H and 13C parahydrogen-induced polarization of acetate and pyruvate esters with ethyl, propyl, and allyl alcoholic moieties. It was found that allyl pyruvate is the most efficiently hyperpolarized compound from those under study, yielding 21 and 5.4% polarization of 1H and 13C nuclei, respectively, in CD3OD solutions. Allyl pyruvate and ethyl acetate were also hyperpolarized in the aqueous phase using homogeneous hydrogenation with parahydrogen over a water-soluble rhodium catalyst. 13C polarization values of 0.82 and 2.1% were obtained for allyl pyruvate and ethyl acetate, respectively. 13C-hyperpolarized methanolic and aqueous solutions of allyl pyruvate and ethyl acetate were employed for in vitro MRI visualization, demonstrating the prospects for translation of the presented approach to biomedical in vivo studies.

Язык оригиналаанглийский
Страницы (с-по)12827-12840
Число страниц14
ЖурналJournal of Physical Chemistry C
Номер выпуска20
СостояниеОпубликовано - 23 мая 2019


Подробные сведения о темах исследования «Parahydrogen-Induced Polarization of 1-<sup>13</sup>C-Acetates and 1-<sup>13</sup>C-Pyruvates Using Sidearm Hydrogenation of Vinyl, Allyl, and Propargyl Esters». Вместе они формируют уникальный семантический отпечаток (fingerprint).