Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives

Veronika V Zlobina, Alexey S Kiryutin, Igor A Nikovskiy, Oleg I Artyushin, Vitaly P Kozinenko, Alexander S Peregudov, Alexandra V Yurkovskaya, Valentin V Novikov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to 1H and 31P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the 31P nucleus.

Язык оригиналаанглийский
Номер статьи557
ЖурналInternational Journal of Molecular Sciences
Том24
Номер выпуска1
Ранняя дата в режиме онлайн29 дек. 2022
DOI
СостояниеОпубликовано - янв. 2023

Предметные области OECD FOS+WOS

  • 1.04 ХИМИЧЕСКИЕ НАУКИ
  • 2.04 ХИМИЧЕСКИЕ ТЕХНОЛОГИИ
  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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