On the Relationship between Regulatory and Exomic DNA Markers

Sergey Postovalov, Vladimir Berikov, Leonid Bryzgalov, Elena Korbolina

Результат исследования: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаярецензирование

Аннотация

A problem of regulatory single nucleotide polymorphism (SNP) prediction based on the presence of exomic SNPs is considered. Usually, regulatory polymorphisms are located in the non-coding region of DNA, therefore they cannot be determined during RNA sequencing. Thus, there is a problem of regulatory polymorphisms prediction by the presence of certain polymorphisms in the DNA coding region. The prediction can be made if there is a strong relationship between regulatory and exomic polymorphism. Chi-square test statistic and normalized Hamming distance for linkage disequilibrium are compared. The results of study of relationship of some regulatory SNP with exomic SNP are presented. To study the relationship between polymorphisms, the polymorphisms already found from the project database of 1000 genomes have been used. The usage of regression models for this problem is discussed. In general, there is strong relationship between regulatory SNP and exomic SNP and linear regression model significantly describes the relationship between regulatory SNP and exomic SNPs very well, however in some cases usage of more complicated types of regression models is necessary.

Язык оригиналаанглийский
Название основной публикацииProceedings - 2020 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology, USBEREIT 2020
ИздательInstitute of Electrical and Electronics Engineers Inc.
Страницы97-100
Число страниц4
ISBN (электронное издание)9781728131658
DOI
СостояниеОпубликовано - мая 2020
Опубликовано для внешнего пользованияДа
Событие2020 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology, USBEREIT 2020 - Yekaterinburg, Российская Федерация
Продолжительность: 14 мая 202015 мая 2020

Серия публикаций

НазваниеProceedings - 2020 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology, USBEREIT 2020

Конференция

Конференция2020 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology, USBEREIT 2020
СтранаРоссийская Федерация
ГородYekaterinburg
Период14.05.202015.05.2020

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    Postovalov, S., Berikov, V., Bryzgalov, L., & Korbolina, E. (2020). On the Relationship between Regulatory and Exomic DNA Markers. В Proceedings - 2020 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology, USBEREIT 2020 (стр. 97-100). [9117734] (Proceedings - 2020 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology, USBEREIT 2020). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/USBEREIT48449.2020.9117734