Numerical simulation of the inflammatory phase of myocardial infarction

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

The dynamics of death of cardiac muscle cells in the acute phase of myocardial infarction is studied numerically. The problem is considered in local and spatially distributed formulations. The adequacy of the mathematical model is confirmed by the quantitative agreement between the results of numerical solution of the problem and experimental data. The adopted models are used to investigate the trigger mechanism of transition from a favorable scenario for the development of acute myocardial infarction to a scenario with a rapid increase in the level of myocardial damage on the third–fifth day of myocardial infarction. For these scenarios of the development of myocardial infarction, the process of demarcating inflammation is investigated. The results of the studies, including evaluations of the effectiveness of anti-inflammatory cytokine therapeutic strategies, are consistent with available data of laboratory studies.

Язык оригиналаанглийский
Страницы (с-по)441-450
Число страниц10
ЖурналJournal of Applied Mechanics and Technical Physics
Том62
Номер выпуска3
DOI
СостояниеОпубликовано - мая 2021

Предметные области OECD FOS+WOS

  • 2.05 ТЕХНОЛОГИЯ МАТЕРИАЛОВ
  • 1.03 ФИЗИЧЕСКИЕ НАУКИ И АСТРОНОМИЯ
  • 2.03 МЕХАНИКА И МАШИНОСТРОЕНИЕ

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