Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage: Synthesis and Solid-Phase Screening Method

A. S. Pavlova, P. A. Ogurtsova, L. S. Koroleva, I. Y. Serpokrylova, A. A. Lomzov, I. A. Pyshnaya, V. N. Silnikov, D. V. Pyshnyi

Результат исследования: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)

Аннотация

Novel bisimidazole-containing peptidomimetic molecules, which can efficiently cleave RNA in the absence of divalent metal ions have been synthesized. The thymidine 5'-monophosphate derivatives modified with these peptidomimetics have been obtained on CPG (controlled pore glass) using a solid phase azide-alkyne cycloaddition. The ability of all synthesized derivatives to cleave RNA has been demonstrated by a solid-phase screening method. The resulting conjugates have provided a 20–100% cleavage of the RNA target in 18 hours. The results allow us to consider the described strategy as a useful approach for the rapid selection of potentially promising peptidomimetic molecules in order to synthesize reactive constructs on their basis.

Язык оригиналаанглийский
Страницы (с-по)813-824
Число страниц12
ЖурналRussian Journal of Bioorganic Chemistry
Том45
Номер выпуска6
DOI
СостояниеОпубликовано - 1 ноя 2019

Fingerprint Подробные сведения о темах исследования «Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage: Synthesis and Solid-Phase Screening Method». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать