Аннотация
Novel bisimidazole-containing peptidomimetic molecules, which can efficiently cleave RNA in the absence of divalent metal ions have been synthesized. The thymidine 5'-monophosphate derivatives modified with these peptidomimetics have been obtained on CPG (controlled pore glass) using a solid phase azide-alkyne cycloaddition. The ability of all synthesized derivatives to cleave RNA has been demonstrated by a solid-phase screening method. The resulting conjugates have provided a 20–100% cleavage of the RNA target in 18 hours. The results allow us to consider the described strategy as a useful approach for the rapid selection of potentially promising peptidomimetic molecules in order to synthesize reactive constructs on their basis.
Язык оригинала | английский |
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Страницы (с-по) | 813-824 |
Число страниц | 12 |
Журнал | Russian Journal of Bioorganic Chemistry |
Том | 45 |
Номер выпуска | 6 |
DOI | |
Состояние | Опубликовано - 1 ноя 2019 |