Novel approach to the delivery into the cells and light-activation of the guide RNA for the genome editing CRISPR/Cas9 system

А. Яковлев; Е. Ахметова; Николай Александрович Данилин; Ольга Андреевна Семиколенова; Иван Павлович Вохтанцев; Дарья Вячеславовна Ким; Дмитрий Олегович Жарков; Алия Гусейновна Веньяминова; Дарья Сергеевна Новопашина

Novel approach to the delivery into the cells and light-activation of the guide RNA for the genome editing CRISPR/Cas9 system

А. Яковлев, Е. Ахметова, Николай Александрович Данилин, Ольга Андреевна Семиколенова, Иван Павлович Вохтанцев, Дарья Вячеславовна Ким, Дмитрий Олегович Жарков, Алия Гусейновна Веньяминова, Дарья Сергеевна Новопашина

Результат исследования: Материалы конференций › тезисы › рецензирование

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Аннотация

Use of the CRISPR/Cas9 system for molecular biological and gene engineering purposes is the issue of the day. Effective delivery of the components of system in cells is obligatory for their successful application. The main goal of our study is the development of novel approach for the delivery of guide RNA (crRNA) in the cells. The proposed approach is based on the usage of additional photocleavable oligodeoxyribonucleotide complementary to guide RNA and bearing ligands facilitating the penetration of the whole construction through the cell membrane.

Язык оригинала	английский
Страницы	122
Число страниц	1
Состояние	Опубликовано - июл. 2021
Опубликовано для внешнего пользования	Да
Событие	FEBS 2021. The 45th FEBS Congress - Продолжительность: 3 июл. 2021 → 8 июл. 2021 https://2021.febscongress.org/

Конференция

Конференция	FEBS 2021. The 45th FEBS Congress
Период	03.07.2021 → 08.07.2021
Адрес в сети Интернет	https://2021.febscongress.org/

Предметные области OECD FOS+WOS

1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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2021_FEBS

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Яковлев, А., Ахметова, Е., Данилин, Н. А., Семиколенова, О. А., Вохтанцев, И. П., Ким, Д. В., Жарков, Д. О., Веньяминова, А. Г., & Новопашина, Д. С. (2021). Novel approach to the delivery into the cells and light-activation of the guide RNA for the genome editing CRISPR/Cas9 system. 122. Выдержка из FEBS 2021. The 45th FEBS Congress.

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title = "Novel approach to the delivery into the cells and light-activation of the guide RNA for the genome editing CRISPR/Cas9 system",

abstract = "Use of the CRISPR/Cas9 system for molecular biological and gene engineering purposes is the issue of the day. Effective delivery of the components of system in cells is obligatory for their successful application. The main goal of our study is the development of novel approach for the delivery of guide RNA (crRNA) in the cells. The proposed approach is based on the usage of additional photocleavable oligodeoxyribonucleotide complementary to guide RNA and bearing ligands facilitating the penetration of the whole construction through the cell membrane.",

author = "А. Яковлев and Е. Ахметова and Данилин, {Николай Александрович} and Семиколенова, {Ольга Андреевна} and Вохтанцев, {Иван Павлович} and Ким, {Дарья Вячеславовна} and Жарков, {Дмитрий Олегович} and Веньяминова, {Алия Гусейновна} and Новопашина, {Дарья Сергеевна}",

note = "The reported study was funded by RFBR, project number 19-34-51026.; null ; Conference date: 03-07-2021 Through 08-07-2021",

year = "2021",

month = jul,

language = "English",

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Яковлев, А, Ахметова, Е, Данилин, НА, Семиколенова, ОА, Вохтанцев, ИП, Ким, ДВ , Жарков, ДО, Веньяминова, АГ & Новопашина, ДС 2021, 'Novel approach to the delivery into the cells and light-activation of the guide RNA for the genome editing CRISPR/Cas9 system', FEBS 2021. The 45th FEBS Congress, 03.07.2021 - 08.07.2021 стр. 122.

Novel approach to the delivery into the cells and light-activation of the guide RNA for the genome editing CRISPR/Cas9 system. / Яковлев, А.; Ахметова, Е.; Данилин, Николай Александрович и др.

2021. 122 Выдержка из FEBS 2021. The 45th FEBS Congress.

Результат исследования: Материалы конференций › тезисы › рецензирование

TY - CONF

T1 - Novel approach to the delivery into the cells and light-activation of the guide RNA for the genome editing CRISPR/Cas9 system

AU - Яковлев, А.

AU - Ахметова, Е.

AU - Данилин, Николай Александрович

AU - Семиколенова, Ольга Андреевна

AU - Вохтанцев, Иван Павлович

AU - Ким, Дарья Вячеславовна

AU - Жарков, Дмитрий Олегович

AU - Веньяминова, Алия Гусейновна

AU - Новопашина, Дарья Сергеевна

N1 - The reported study was funded by RFBR, project number 19-34-51026.

PY - 2021/7

Y1 - 2021/7

N2 - Use of the CRISPR/Cas9 system for molecular biological and gene engineering purposes is the issue of the day. Effective delivery of the components of system in cells is obligatory for their successful application. The main goal of our study is the development of novel approach for the delivery of guide RNA (crRNA) in the cells. The proposed approach is based on the usage of additional photocleavable oligodeoxyribonucleotide complementary to guide RNA and bearing ligands facilitating the penetration of the whole construction through the cell membrane.

AB - Use of the CRISPR/Cas9 system for molecular biological and gene engineering purposes is the issue of the day. Effective delivery of the components of system in cells is obligatory for their successful application. The main goal of our study is the development of novel approach for the delivery of guide RNA (crRNA) in the cells. The proposed approach is based on the usage of additional photocleavable oligodeoxyribonucleotide complementary to guide RNA and bearing ligands facilitating the penetration of the whole construction through the cell membrane.

M3 - Abstract

SP - 122

Y2 - 3 July 2021 through 8 July 2021

ER -