No Catalyst Added Hydrogen Peroxide Oxidation of Dextran: An Environmentally Friendly Route to Multifunctional Polymers

Ekaterina V. Pronina, Yuri A. Vorotnikov, Tatiana N. Pozmogova, Anastasiya O. Solovieva, Svetlana M. Miroshnichenko, Pavel E. Plyusnin, Denis P. Pishchur, Ilia V. Eltsov, Mariya V. Edeleva, Michael A. Shestopalov, Olga A. Efremova

Результат исследования: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)

Аннотация

The paper demonstrates a "greener" oxidation of dextran polymer of various molecular masses, the component of many industrially and pharmaceutically important materials, by aqueous H2O2 in a no catalyst added setting that produced a multifunctional oxidized dextran. Specifically, on the top of common functional groups (hydroxo, carbonyl, and carboxylic acids), the freshly peroxide oxidized dextran had also a significant number of peroxo-groups, which endowed the polymer with significant cytotoxic properties, as demonstrated on a larynx carcinoma cell line. We also have shown that the peroxo-groups could be easily removed in an alkaline media to yield nontoxic oxidized dextran polymers.

Язык оригиналаанглийский
Страницы (с-по)5371-5379
Число страниц9
ЖурналACS Sustainable Chemistry and Engineering
Том8
Номер выпуска13
DOI
СостояниеОпубликовано - 6 апр 2020

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