N,O-bidentate ligands-based salicylic spiroborates: A bright frontier of bioimaging

Kseniya I. Lugovik, Timur O. Fomin, Artem S. Minin, Varvara A. Pozdina, Vadim A. Shevyrin, Enrico Benassi, Nataliya P. Belskaya

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

A new series of salicylic spiroborate complexes (SSBs) based on N,O-bidentate 2-(tert-cycloalkylamino)-5-(3-(arylamino)acryloyl)thiophene-3-carbonitriles (NO-SSBs) was obtained and characterized. The optical properties of these compounds were studied and compared with those of analogous BF2-based complexes. The geometries and electronic structures of the NO-SSBs in the ground and excited states, especially their key N–B–O link, were revealed using quantum chemical calculations and compared with the experimental data and photophysical characteristics. Hydrolytic dissociation and photodissociation were considered, and the effects of the NO-SSB structure and nature of the solvent on these reactions were established. Biological investigations elucidated the NO-SSBs ability to penetrate living and fixed cells and selectively accumulate in the endoplasmic reticulum (ER) and Golgi complex. Comparison of the NO-SSBs’ characteristics with those of a commercial dye demonstrated the superiority of their properties and prospects for application in the bio-visualization of the ER and Golgi complex.

Язык оригиналаанглийский
Номер статьи110165
ЖурналDyes and Pigments
Том200
DOI
СостояниеОпубликовано - апр. 2022

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