New reaction products of acetylacetone with semicarbazide derivatives

Vera S. Glukhacheva, Sergey G. Il'Yasov, Igor V. Kazantsev, Elena O. Shestakova, Dmitri S. Il'Yasov, Ilia V. Eltsov, Andrey A. Nefedov, Yuri V. Gatilov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

1 Цитирования (Scopus)

Аннотация

A new approach is suggested herein for the synthesis of pyrazole derivatives by reacting 4-nitrosemicarbazide with acetylacetone. Additional studies were done on the reaction of acetylacetone with semicarbazide and its derivatives (4-aminosemicarbazide, methylsemicarbazide, and dimethylsemicarbazide). The study on the reaction with acetylacetone resulted in monocyclic 3, 5-dimethyl-N-nitropyrazole-1-carboxamide, monocyclic 5-hydroxy-3, 5-dimethyl-2-pyrazoline, and bicyclic bis(3, 5- dimethylpyrazole-1-carbonyl)hydrazine, and conditions for the formation of acetone semicarbazone were identified. The structures of the resultant compounds were validated by physicochemical analytical methods, including X-ray diffraction. The computer-aided screening in the PASS prediction software discovered a high biological activity of the newly obtained compounds.

Язык оригиналаанглийский
Страницы (с-по)8637–8645
Число страниц9
ЖурналACS Omega
Том6
Номер выпуска12
DOI
СостояниеОпубликовано - 30 мар 2021

Предметные области OECD FOS+WOS

  • 2.04 ХИМИЧЕСКИЕ ТЕХНОЛОГИИ
  • 1.04 ХИМИЧЕСКИЕ НАУКИ

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