Аннотация

Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments.

Язык оригиналаанглийский
Страницы (с-по)330-336
Число страниц7
ЖурналRussian Journal of Bioorganic Chemistry
Том44
Номер выпуска3
DOI
СостояниеОпубликовано - 1 мая 2018

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