New hydrazinothiazole derivatives of usnic acid as potent TDP1 inhibitors

Aleksander S. Filimonov, Arina A. Chepanova, Olga A. Luzina, Alexandra L. Zakharenko, Olga D. Zakharova, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Maxim S. Kuprushkin, Anton V. Kolotaev, Derenik S. Khachatryan, Jinal Patel, Ivanhoe K.H. Leung, Raina Chand, Daniel M. Ayine-Tora, Johannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik

Результат исследования: Научные публикации в периодических изданияхстатья

6 Цитирования (Scopus)

Аннотация

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can potentially improve therapeutic response to many chemotherapeutic regimes. A new set of usnic acid derivatives with hydrazonothiazole pharmacophore moieties were synthesized and evaluated as Tdp1 inhibitors. Most of these compounds were found to be potent inhibitors with IC50 values in the low nanomolar range. The activity of the compounds was verified by binding experiments and supported by molecular modeling. The ability of the most effective inhibitors, used at non-toxic concentrations, to sensitize tumors to the anticancer drug topotecan was also demonstrated. The order of administration of the inhibitor and topotecan on their synergistic effect was studied, suggesting that prior or simultaneous introduction of the inhibitor with topotecan is the most effective.

Язык оригиналаанглийский
Номер статьи3711
ЖурналMolecules
Том24
Номер выпуска20
DOI
СостояниеОпубликовано - 15 окт 2019

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  • Цитировать

    Filimonov, A. S., Chepanova, A. A., Luzina, O. A., Zakharenko, A. L., Zakharova, O. D., Ilina, E. S., Dyrkheeva, N. S., Kuprushkin, M. S., Kolotaev, A. V., Khachatryan, D. S., Patel, J., Leung, I. K. H., Chand, R., Ayine-Tora, D. M., Reynisson, J., Volcho, K. P., Salakhutdinov, N. F., & Lavrik, O. I. (2019). New hydrazinothiazole derivatives of usnic acid as potent TDP1 inhibitors. Molecules, 24(20), [3711]. https://doi.org/10.3390/molecules24203711