New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv

Olga I. Yarovaya, Kseniya S. Kovaleva, Anna A. Zaykovskaya, Liudmila N. Yashina, Nadezda S. Scherbakova, Dmitry N. Scherbakov, Sophia S. Borisevich, Fedor I. Zubkov, Alexandra S. Antonova, Roman Yu Peshkov, Ilia V. Eltsov, Oleg V. Pyankov, Rinat A. Maksyutov, Nariman F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

1 Цитирования (Scopus)

Аннотация

This work presents the design and synthesis of camphor, fenchone, and norcamphor N-acylhydrazone derivatives as a new class of inhibitors of the Hantaan virus, which causes haemorrhagic fever with renal syndrome (HFRS). A cytopathic model was developed for testing chemotherapeutics against the Hantaan virus, strain 76–118. In addition, a study of the antiviral activity was carried out using a pseudoviral system. It was found that the hit compound possesses significant activity (IC50 = 7.6 ± 2 µM) along with low toxicity (CC50 > 1000 µM). Using molecular docking procedures, the binding with Hantavirus nucleoprotein was evaluated and the correlation between the structure of the synthesised compounds and the antiviral activity was established.

Язык оригиналаанглийский
Номер статьи127926
ЖурналBioorganic and Medicinal Chemistry Letters
Том40
Ранняя дата в режиме онлайн9 мар 2021
DOI
СостояниеОпубликовано - 15 мая 2021

Предметные области OECD FOS+WOS

  • 1.04 ХИМИЧЕСКИЕ НАУКИ
  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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