New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections

Evgenii V. Suslov, Evgenii S. Mozhaytsev, Dina V. Korchagina, Nikolay I. Bormotov, Olga I. Yarovaya, Konstantin P. Volcho, Olga A. Serova, Alexander P. Agafonov, Rinat A. Maksyutov, Larisa N. Shishkina, Nariman F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

4 Цитирования (Scopus)

Аннотация

Currently, the spectrum of agents against orthopoxviruses, in particular smallpox, is very narrow. Despite the fact that smallpox is well controlled, there is, for many reasons, a real threat of epidemics associated with this or a similar virus. In order to search for new low molecular weight orthopoxvirus inhibitors, a series of amides combining adamantane and monoterpene moieties were synthesized using 1- and 2-adamantanecarboxylic acids as well as myrtenic, citronellic and camphorsulfonic acids as acid components. The produced compounds exhibited high activity against the vaccinia virus (an enveloped virus belonging to the poxvirus family), which was combined with low cytotoxicity. Some compounds had a selectivity index higher than that of the reference drug cidofovir; the highest SI = 1123 was exhibited by 1-adamantanecarboxylic acid amide containing the (-)-10-amino-2-pinene moiety. The produced compounds demonstrated inhibitory activity against other orthopoxviruses: cowpox virus (SI = 30-406) and ectromelia virus (mousepox virus, SI = 39-707). This journal is

Язык оригиналаанглийский
Страницы (с-по)1185-1195
Число страниц11
ЖурналRSC Medicinal Chemistry
Том11
Номер выпуска10
DOI
СостояниеОпубликовано - окт 2020

Предметные области OECD FOS+WOS

  • 3.01 ФУНДАМЕНТАЛЬНАЯ МЕДИЦИНА
  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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