Natural and artificial mechanisms of mitochondrial genome elimination

Elvira G. Zakirova, Vladimir V. Muzyka, Ilya O. Mazunin, Konstantin E. Orishchenko

    Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование

    Аннотация

    The generally accepted theory of the genetic drift of mitochondrial alleles during mammalian ontogenesis is based on the presence of a selective bottleneck in the female germline. However, there is a variety of different theories on the pathways of genetic regulation of mitochondrial DNA (mtDNA) dynamics in oogenesis and adult somatic cells. The current review summarizes present knowledge on the natural mechanisms of mitochondrial genome elimination during mammalian development. We also discuss the variety of existing and developing methodologies for artificial manipulation of the mtDNA heteroplasmy level. Understanding of the basics of mtDNA dynamics will shed the light on the pathogenesis and potential therapies of human diseases associated with mitochondrial dysfunction.

    Язык оригиналаанглийский
    Номер статьи76
    Страницы (с-по)1-22
    Число страниц22
    ЖурналLife
    Том11
    Номер выпуска2
    DOI
    СостояниеОпубликовано - фев 2021

    Fingerprint

    Подробные сведения о темах исследования «Natural and artificial mechanisms of mitochondrial genome elimination». Вместе они формируют уникальный семантический отпечаток (fingerprint).

    Цитировать