TY - JOUR
T1 - Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds
AU - Cheplakova, Anastasia M.
AU - Solovieva, Anastasiya O.
AU - Pozmogova, Tatiana N.
AU - Vorotnikov, Yuri A.
AU - Brylev, Konstantin A.
AU - Vorotnikova, Natalya A.
AU - Vorontsova, Elena V.
AU - Mironov, Yuri V.
AU - Poveshchenko, Alexander F.
AU - Kovalenko, Konstantin A.
AU - Shestopalov, Michael A.
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Inclusion compounds of photoluminescent hexamolybdenum cluster complexes in the chromium terephthalate metal-organic framework, MIL-101 (MIL, Matérial Institut Lavoisier) were successfully synthesized in two different ways and characterized by means of powder X-Ray diffraction, chemical analysis and nitrogen sorption. Some important functional properties of hexamolybdenum cluster complexes for biological and medical applications, in particular singlet oxygen generation ability, luminescence properties, cellular uptake behavior and cytotoxicity were studied. It was revealed that the inclusion compounds possessed significant singlet oxygen generation activity. The materials obtained showed a low cytotoxicity, thus allowing them to be used in living cells. Confocal microscopy of human larynx carcinoma (Hep-2) cells incubated with the inclusion compounds showed that MIL-101 performed as a nanocarrier adhering to the external cell membrane surface and releasing the cluster complexes which that penetrated into the cells. Moreover, photoinduced generation of reactive oxygen species (ROS) in Hep-2 cells incubated with inclusion compounds was demonstrated. The cluster supported on MIL-101 was shown to possess in vivo phototoxicity.
AB - Inclusion compounds of photoluminescent hexamolybdenum cluster complexes in the chromium terephthalate metal-organic framework, MIL-101 (MIL, Matérial Institut Lavoisier) were successfully synthesized in two different ways and characterized by means of powder X-Ray diffraction, chemical analysis and nitrogen sorption. Some important functional properties of hexamolybdenum cluster complexes for biological and medical applications, in particular singlet oxygen generation ability, luminescence properties, cellular uptake behavior and cytotoxicity were studied. It was revealed that the inclusion compounds possessed significant singlet oxygen generation activity. The materials obtained showed a low cytotoxicity, thus allowing them to be used in living cells. Confocal microscopy of human larynx carcinoma (Hep-2) cells incubated with the inclusion compounds showed that MIL-101 performed as a nanocarrier adhering to the external cell membrane surface and releasing the cluster complexes which that penetrated into the cells. Moreover, photoinduced generation of reactive oxygen species (ROS) in Hep-2 cells incubated with inclusion compounds was demonstrated. The cluster supported on MIL-101 was shown to possess in vivo phototoxicity.
KW - Hep-2 cells
KW - Luminescence
KW - MIL-101
KW - Molybdenum clusters
KW - Phototoxicity
KW - Singlet oxygen
KW - Reactive Oxygen Species/metabolism
KW - Cell Line
KW - Humans
KW - Molybdenum/chemistry
KW - Antineoplastic Agents/chemistry
KW - Coordination Complexes/chemistry
KW - Drug Carriers/chemistry
KW - Laryngeal Neoplasms/drug therapy
KW - HEXANUCLEAR MOLYBDENUM CLUSTERS
KW - PHOTODYNAMIC THERAPY
KW - DRUG-DELIVERY
KW - COMPLEXES
KW - ENCAPSULATION
KW - LUMINESCENCE PROPERTIES
KW - CHROMIUM(III) TEREPHTHALATE
KW - SILICA NANOPARTICLES
KW - CYTOTOXICITY
KW - SORPTION PROPERTIES
UR - http://www.scopus.com/inward/record.url?scp=84994758795&partnerID=8YFLogxK
U2 - 10.1016/j.jinorgbio.2016.11.014
DO - 10.1016/j.jinorgbio.2016.11.014
M3 - Article
C2 - 27842246
AN - SCOPUS:84994758795
VL - 166
SP - 100
EP - 107
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
SN - 0162-0134
ER -