Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells

Alexey Evdokimov, Irina Petruseva, Aleksei Popov, Olga Koval, Olga Lavrik

Результат исследования: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаярецензирование

Аннотация

Naked mole rat is the long-lived and tumor-resistant rodent. Naked mole rat possesses multiple adaptations that may contribute to longevity and cancer-resistance. Higher activity of DNA excision repair systems and their faster recovery after genotoxic impact as compare with Mus musculus directly demonstrated in our previous investigation contribute to longevity and cancer resistance of naked mole rat. In the present study the DNA-damage-induced apoptosis in naked mole rat fibroblasts was studied using conventional methods. The ability of naked mole rat cells to undergo regulated cell death in response to genotoxic stress is another group of cell defense mechanisms. Naked mole rat skin fibroblasts were demonstrated to be much more resistant towards proapoptotic reagents methyl methanesulfonate, 5-fluorouracil and etoposide as compared with fibroblasts of Mus musculus. Naked mole rat cells have demonstrated limited apoptotic response and seem to undergo also other-type regulated cell death under severe genotoxic stress.

Язык оригиналаанглийский
Название основной публикацииINTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020)
РедакторыO Kovtun, Bazarnyi
ИздательUniversity of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions
Число страниц6
DOI
СостояниеОпубликовано - 2020
СобытиеInternational Scientific Conference on Longevity Interventions (ICLI) - Ekaterinburg
Продолжительность: 20 апр 202022 апр 2020

Серия публикаций

НазваниеBIO Web of Conferences
ИздательE D P SCIENCES
Том22
ISSN (печатное издание)2117-4458

Конференция

КонференцияInternational Scientific Conference on Longevity Interventions (ICLI)
ГородEkaterinburg
Период20.04.202022.04.2020

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