Molecular determinants possibly involved in the adaptation of pandemic A(H1N1)09 influenza virus to a new host

Elena Prokopyeva, Alesia Romanovskaya, Kirill Sharshov, Ivan Sobolev, Alexander Alekseev, Alexander Durymanov, Alexander Shestopalov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Aim: To determine the molecular basis of A(H1N1)pdm09 virus adaptation to a new host. Methods: The pandemic virus A/Russia/01/2009 was adapted to mice by serial lung-to-lung passages. The growth properties, pathogenicity and genome sequences of the mouse-adapted virus were compared with those of the parental strain. Results: The A(H1N1)pdm09 virus caused mouse death after only six lung-to-lung passages. Mutations in the influenza virus antigen were found in the brain, liver, kidney and in intestine by immunohistochemistry. Conclusion: Our findings suggest that multiple mutations in the viral genome promote rapid adaptation of the A(H1N1)pdm09 virus and cause generalized infection in mice.

Язык оригиналаанглийский
Страницы (с-по)491-498
Число страниц8
ЖурналFuture Virology
Том12
Номер выпуска9
DOI
СостояниеОпубликовано - сен 2017

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