Modular lentiviral vector system for chimeric antigen receptor design optimization

S. V. Kulemzin, N. A. Chikaev, O. Y. Volkova, V. V. Kuznetsova, A. V. Taranin, A. A. Gorchakov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

2 Цитирования (Scopus)


The article reports the development of a collection of lentiviral vector constructs enabling time-efficient production and testing of different variants of chimeric antigen receptors (CAR). These artificial surface proteins make it possible to redirect the activity of immune cytotoxic T-cells towards cancer cells. Chimeric antigen receptors usually encompass four functional modules, namely, antigen recognition, flexible linker, transmembrane, and signal modules. The use of modules with different properties allows modulating the affinity and specificity of CAR interaction with target antigens, as well as intensity and quality of activation signaling, which determines the cytotoxic properties of CAR T-cells, as well as their proliferation rate and time of persistence in the organism. The proposed vector system make it possible to easily test various combinations of CAR modules while its being open to distribution allows the direct comparison of the results obtained by different scientific groups.

Язык оригиналаанглийский
Страницы (с-по)107-114
Число страниц8
ЖурналRussian Journal of Bioorganic Chemistry
Номер выпуска2
СостояниеОпубликовано - 1 мар. 2017


Подробные сведения о темах исследования «Modular lentiviral vector system for chimeric antigen receptor design optimization». Вместе они формируют уникальный семантический отпечаток (fingerprint).