Modeling neurodegenerative disorders in zebrafish

Alim A. Bashirzade, Konstantin N. Zabegalov, Andrey D. Volgin, Alisa S. Belova, Konstantin A. Demin, Murilo S. de Abreu, Vladislav Ya Babchenko, Kseniya A. Bashirzade, Konstantin B. Yenkoyan, Maria A. Tikhonova, Tamara G. Amstislavskaya, Allan V. Kalueff

Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование

Аннотация

Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain disorders. Their complex pathogenesis commonly includes genetic and neurochemical deficits, misfolded protein toxicity, demyelination, apoptosis and mitochondrial dysfunctions. Albeit differing in specific underlying mechanisms, neurodegenerative disorders typically display evolutionarily conserved mechanisms across taxa. Here, we review the role of zebrafish models in recapitulating major human and rodent neurodegenerative conditions, demonstrating this species as a highly relevant experimental model for research on neurodegenerative diseases, and discussing how these fish models can further clarify the underlying genetic, neurochemical, neuroanatomical and behavioral pathogenic mechanisms.

Язык оригиналаанглийский
Номер статьи104679
ЖурналNeuroscience and Biobehavioral Reviews
Том138
DOI
СостояниеОпубликовано - июл 2022

Предметные области OECD FOS+WOS

  • 5.01 ПСИХОЛОГИЧЕСКИЕ НАУКИ
  • 3.01 ФУНДАМЕНТАЛЬНАЯ МЕДИЦИНА

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