Mitochondrial dysfunction and potential anticancer therapy

Matilde E. Lleonart, Robert Grodzicki, Dmitri M. Graifer, Alex Lyakhovich

Результат исследования: Научные публикации в периодических изданияхобзорная статья

16 Цитирования (Scopus)

Аннотация

Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposition syndromes with defective DNA damage response (DDR) machinery. Moreover, a recent highlight arises from the detection of MDF in eukaryotic cells upon treatment with antibiotics. In this review, we focus on recent studies of MDF in pathological conditions with a particular emphasis on the effects of various classes of antibiotics on mitochondria. Special attention is given to the role of autophagy/mitophagy in MDF and repurposing antibiotics as anticancer drugs.

Язык оригиналаанглийский
Страницы (с-по)1275-1298
Число страниц24
ЖурналMedicinal Research Reviews
Том37
Номер выпуска6
DOI
СостояниеОпубликовано - 1 ноя 2017

    Fingerprint

Цитировать