Malignant and benign thyroid nodule differentiation through the analysis of blood plasma with terahertz spectroscopy

Maria R. Konnikova, Olga P. Cherkasova, Maxim M. Nazarov, Denis A. Vrazhnov, Yuri V. Kistenev, Sergei E. Titov, Elena V. Kopeikina, Sergei P. Shevchenko, Alexander P. Shkurinov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

The liquid and lyophilized blood plasma of patients with benign or malignant thyroid nodules and healthy individuals were studied by terahertz (THz) time-domain spectroscopy and machine learning. The blood plasma samples from malignant nodule patients were shown to have higher absorption. The glucose concentration and miRNA-146b level were correlated with the sample's absorption at 1 THz. A two-stage ensemble algorithm was proposed for the THz spectra analysis. The first stage was based on the Support Vector Machine with a linear kernel to separate healthy and thyroid nodule participants. The second stage included additional data preprocessing by Ornstein-Uhlenbeck kernel Principal Component Analysis to separate benign and malignant thyroid nodule participants. Thus, the distinction of malignant and benign thyroid nodule patients through their lyophilized blood plasma analysis by terahertz time-domain spectroscopy and machine learning was demonstrated.

Язык оригиналаанглийский
Страницы (с-по)1020-1035
Число страниц16
ЖурналBiomedical Optics Express
Том12
Номер выпуска2
DOI
СостояниеОпубликовано - 1 фев 2021

Предметные области OECD FOS+WOS

  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ
  • 1.03 ФИЗИЧЕСКИЕ НАУКИ И АСТРОНОМИЯ

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