TY - GEN
T1 - Lymph nodes morphology as predictor natural and premature aging
AU - Gorchakova, Olga
AU - Gorchakov, Vladimir
AU - Demchenko, Georgy
N1 - Publisher Copyright:
© 2020 IEEE.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - The research purpose is a comparative characteristic of lymph nodes structure at natural (physiological) aging of Wistar rats and premature of OXYS rats. We used a morphological method of a research. Age changes of lymph nodes structure differ at rats of OXYS and Wistar. The age-induced changes of lymphoid tissue of Wistar and OXYS rats differ with type of the immune response and morphological variant of lymph nodes structure. The immune response on humoral type is formed in mesenteric and inguinal lymph nodes, and the immune response on cellular type is formed in the tracheobronchial lymph node. The sizes of compartments of lymph nodes reach the greatest development at three-months age of Wistar rats, but it is not observed at OXYS rats. Lymph nodes compartments undergo involution when aging. We noted reduction of structures of cortical substance, especially lymphoid follicles and a paracortex, and expansion of medullary substance in lymph nodes. Lymph nodes are subject big morphological changes at OXYS rats, than at old rats of Wistar. Observed changes of structure of lymph nodes have the region-dependent character and can be considered as aging predictors with the indication on weakening of a drainage and immune function of lymph nodes.
AB - The research purpose is a comparative characteristic of lymph nodes structure at natural (physiological) aging of Wistar rats and premature of OXYS rats. We used a morphological method of a research. Age changes of lymph nodes structure differ at rats of OXYS and Wistar. The age-induced changes of lymphoid tissue of Wistar and OXYS rats differ with type of the immune response and morphological variant of lymph nodes structure. The immune response on humoral type is formed in mesenteric and inguinal lymph nodes, and the immune response on cellular type is formed in the tracheobronchial lymph node. The sizes of compartments of lymph nodes reach the greatest development at three-months age of Wistar rats, but it is not observed at OXYS rats. Lymph nodes compartments undergo involution when aging. We noted reduction of structures of cortical substance, especially lymphoid follicles and a paracortex, and expansion of medullary substance in lymph nodes. Lymph nodes are subject big morphological changes at OXYS rats, than at old rats of Wistar. Observed changes of structure of lymph nodes have the region-dependent character and can be considered as aging predictors with the indication on weakening of a drainage and immune function of lymph nodes.
KW - gerontology
KW - lymph node
KW - OXYS and Wistar rats
KW - premature aging
UR - http://www.scopus.com/inward/record.url?scp=85094818512&partnerID=8YFLogxK
UR - https://elibrary.ru/item.asp?id=45205805
U2 - 10.1109/CSGB51356.2020.9214771
DO - 10.1109/CSGB51356.2020.9214771
M3 - Conference contribution
AN - SCOPUS:85094818512
T3 - Proceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
SP - 170
EP - 173
BT - Proceedings - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 Cognitive Sciences, Genomics and Bioinformatics, CSGB 2020
Y2 - 6 July 2020 through 10 July 2020
ER -