Low-Flammable Parahydrogen-Polarized MRI Contrast Agents

Baptiste Joalland, Nuwandi M. Ariyasingha, Hassan R. Younes, Shiraz Nantogma, Oleg G. Salnikov, Nikita V. Chukanov, Kirill V. Kovtunov, Igor V. Koptyug, Juri G. Gelovani, Eduard Y. Chekmenev

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

2 Цитирования (Scopus)

Аннотация

Many MRI contrast agents formed with the parahydrogen-induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high-throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics.

Язык оригиналаанглийский
Страницы (с-по)2774-2781
Число страниц8
ЖурналChemistry - A European Journal
Том27
Номер выпуска8
Ранняя дата в режиме онлайн28 окт 2020
DOI
СостояниеОпубликовано - 5 фев 2021

Предметные области OECD FOS+WOS

  • 1.04.DY ХИМИЯ, МУЛЬТИДИСЦИПЛИНАРНАЯ

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