Light-Stimulated Generation of Free Radicals by Quinones-Chelators

Irina D. Markova, Nikolay E. Polyakov, Olga Yu Selyutina, Lidia G. Fedenok, Kirill Yu Fedotov, Irina A. Slepneva, Tatyana V. Leshina, Andrey G. Pokrovsky, Nadezhda V. Vasilieva, Lev M. Weiner

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

4 Цитирования (Scopus)

Аннотация

The role of metal ions in the mechanism of light-stimulated redox activity of potential anticancer agent 2-phenyl-4-(butylamino)naphtha[2,3-h]quinoline-7,12-dione (Qc) has been studied by CIDNP (chemically induced dynamic nuclear polarization) and EPR methods. The photo-induced oxidation of NADH and its synthetic analog-substituted dihydropyridine (DHP)-by quinone Qc was used as a model. The Qc capability of producing chelating complexes with divalent metal ions of Fe, Zn and Ca was studied quantitatively by optical absorption spectroscopy. A significant decrease of electrochemical reduction potential of Qc (ΔE=0.4-0.6 eV for ACN and ACN/PBS solutions) in chelating complexes and in protonated form of Qc was observed. A pronounced increase in efficiency of DHP oxidation in chelating complexes with Zn2+ and Ca2+ ions compared with free Qc was demonstrated. The yields of free radicals, including reactive oxygen species (ROS) and reaction products, were a few times higher than those in the absence of metal ions. Application of such chelating compounds to enhance ROS generation looks very promising for anti-cancer therapy, including the photodynamic therapy.

Язык оригиналаанглийский
Страницы (с-по)369-389
Число страниц21
ЖурналZeitschrift fur Physikalische Chemie
Том231
Номер выпуска2
DOI
СостояниеОпубликовано - 1 фев 2017

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