We report new results of a comprehensive study into Carboniferous–Early Permian granite magmatism of the northern Taimyr Peninsula, Russia (southern part of the Kara Terrane). U-Pb zircon ages (SHRIMP and LA–ICP–MS) represent the crystallization ages of these intrusions and range from ca. 344.5 to 288.4 Ma, defining the onset of granite magmatism during the Early Carboniferous (Visean; ca. 344 Ma) and its termination in the Early Permian (Artinskian; ca. 288 Ma). Ar-Ar dating of micas and amphiboles indicates that Late Palaeozoic tectonic activity in northern Taimyr ceased during the Middle Permian (Roadian; ca. 272 Ma). Rb/Sr and Sm/Nd isotopic data from the same intrusions, show initial (87Sr/86Sr)i ratios of between 0.70288 and 0.71027, with εNd(t) values range between −3.3 and +3.1. The combined geochemical and isotopic compositions of the granites describe an affinity to peraluminous I-type granites, probably formed in an Andean-type active continental margin setting. Our new geochemical, isotopic, and geochronological data indicate the existence of a long-lived (ca. 56 Myr) Andean-type active continental margin along the southern edge of the Kara Terrane during the Late Palaeozoic. Furthermore, our study reveals a causal relationship between Late Palaeozoic magmatism across northern Taimyr and closure of the Uralian Ocean.