Investigation of cytotoxic and antioxidative activity of 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins

Artemii A. Ivanov, Egor A. Ukladov, Stepan A. Kremis, Sodbo Z. Sharapov, Sergey I. Baiborodin, Alla V. Lipeeva, Elvira E. Shults, Tatiana S. Golubeva

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

High biological activity of natural furocoumarins is often linked to a series of adverse side effects, e.g., genotoxicity. This makes it desirable to develop semi-synthetic derivatives with reduced negative activity while retaining or even enhancing the positive properties. Previously, we have studied the genotoxic activity of a library of twenty-one 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins and identified modifications that minimize the negative properties. In the current article, we report on an investigation into the cytotoxic activity of the same library. We have aimed to rank the substances in order of the severity of their cytotoxicity and therefore to predict, with the use of statistical processing, the most promising substituents for the furocoumarin scaffold.

Язык оригиналаанглийский
Страницы (с-по)1321-1330
Число страниц10
ЖурналProtoplasma
Том259
Номер выпуска5
Ранняя дата в режиме онлайн26 янв. 2022
DOI
СостояниеОпубликовано - сент. 2022

Предметные области OECD FOS+WOS

  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ
  • 1.06.DE НАУКИ О РАСТЕНИЯХ
  • 1.06.DR КЛЕТОЧНАЯ БИОЛОГИЯ

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