To meet society's need to better understand and respond to complex, interwoven problems of climate and sustainability, we herein introduce an integrative framework being applied in a US university setting for conceptualising, designing and deploying educational programs that interconnect climate change resilience (CCR) with sustainable development (SD). The framework weaves together five main strands of integration: 1) socio-political stakeholder interests and influences; 2) development sectors; 3) knowledge types; 4) socio-technical capacities, including education; 5) the smart networking of project sites across varying geographical scales. We pose and answer: what kinds of integrative educational programs, curricula and project practicums can enable transformations in CCRxSD practice? A philosophical foundation undergirds the knowledge and skills base of the suggested programming. Two collaborative case studies illustrate integrative practicums: 1) Fisherville Mill Site, Grafton, Massachusetts, USA - a showcase in urban sustainability; 2) Fijian Islands - a prospective case study in integrative CCRxSD program design.