In this Review, diverse chemical problems that have been approached by means of infrared thermography (IRT) are covered in depth. Moreover, some novel steps forward in this field are made, described and discussed. Namely, the latest-generation IRT performance capabilities are harnessed in full; the initial phase of catalytic CO oxidation (called “fast ignition”) is presented at the 0.01 s temporal resolution; at the same resolution, the thermal manifestation of the adsorption-desorption wave propagation after the gaseous reactant pulsed (0.6 s) wetting is exhibited. Furthermore, a radical difference in the thermal behavior of differently calcined γ-Al2O3 supported Au catalysts, which underwent successive H2O and CO attacks, is demonstrated, and the generally accepted fact that the catalyst temperature reflects the catalytic activity is validated experimentally. It is shown that latest-generation IRT may serve as unique and highly informative research tool in chemistry.