Induced pluripotent stem cell line, IMGTi003-A, derived from skin fibroblasts of an intellectually disabled patient with ring chromosome 13

T. V. Nikitina, A. G. Menzorov, A. A. Kashevarova, M. M. Gridina, A. A. Khabarova, Yu S. Yakovleva, M. E. Lopatkina, I. E. Pristyazhnyuk, S. A. Vasilyev, O. L. Serov, I. N. Lebedev

Результат исследования: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Аннотация

Skin fibroblasts from a patient with neurodevelopmental and speech delay, anxiety disorder, macrocephaly, microorchidism, multiple anomalies of internal organs and ring chromosome 13 were reprogrammed into induced pluripotent stem cells (iPSCs) to generate a clonal stem cell line IMGTi003-A (iTAF6-6). IMGTi003-A pluripotency was demonstrated by three germ layer differentiation capacity in vitro, and this cell line had a mosaic karyotype with 46,XY,r(13) as a predominant cell subpopulation. IMGTi003-A line is a good model for studying of the mitotic instability of the ring chromosome 13.

Язык оригиналаанглийский
Страницы (с-по)260-264
Число страниц5
ЖурналStem Cell Research
Том33
DOI
СостояниеОпубликовано - 1 дек 2018

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  • Цитировать

    Nikitina, T. V., Menzorov, A. G., Kashevarova, A. A., Gridina, M. M., Khabarova, A. A., Yakovleva, Y. S., Lopatkina, M. E., Pristyazhnyuk, I. E., Vasilyev, S. A., Serov, O. L., & Lebedev, I. N. (2018). Induced pluripotent stem cell line, IMGTi003-A, derived from skin fibroblasts of an intellectually disabled patient with ring chromosome 13. Stem Cell Research, 33, 260-264. https://doi.org/10.1016/j.scr.2018.11.009