Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution

O. B. Morozova; N. N. Fishman; A. V. Yurkovskaya

doi:10.1039/c7cp03797j

Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution

O. B. Morozova, N. N. Fishman, A. V. Yurkovskaya

Лаборатория магнитного резонанса в химии, биологии и медицине ФЕН

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

7 Цитирования (Scopus)

Аннотация

By using the time-resolved chemically induced dynamic nuclear polarization technique, we show that the neutral guanosyl radical, G(-H), formed in the reaction of guanosine-5′-monophosphate with a triplet-excited 3,3′,4,4′-tetracarboxy benzophenone in neutral aqueous solution, protonates readily at the N7 position with the formation of a new guanosyl cation radical (G⁺)'.

Язык оригинала	английский
Страницы (с-по)	21262-21266
Число страниц	5
Журнал	Physical Chemistry Chemical Physics
Том	19
Номер выпуска	32
DOI	https://doi.org/10.1039/c7cp03797j
Состояние	Опубликовано - 28 авг 2017

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10.1039/c7cp03797j

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abstract = "By using the time-resolved chemically induced dynamic nuclear polarization technique, we show that the neutral guanosyl radical, G(-H), formed in the reaction of guanosine-5′-monophosphate with a triplet-excited 3,3′,4,4′-tetracarboxy benzophenone in neutral aqueous solution, protonates readily at the N7 position with the formation of a new guanosyl cation radical (G+)'.",

keywords = "ELECTRON-REDUCTION POTENTIALS, TIME-RESOLVED CIDNP, GUANINE OXIDATION, PULSE-RADIOLYSIS, REDOX CHEMISTRY, CELLULAR-DNA, DAMAGE, SPECTROSCOPY, NUCLEOTIDES, CATIONS",

author = "Morozova, {O. B.} and Fishman, {N. N.} and Yurkovskaya, {A. V.}",

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Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution. / Morozova, O. B.; Fishman, N. N.; Yurkovskaya, A. V.

В: Physical Chemistry Chemical Physics, Том 19, № 32, 28.08.2017, стр. 21262-21266.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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KW - TIME-RESOLVED CIDNP

KW - GUANINE OXIDATION

KW - PULSE-RADIOLYSIS

KW - REDOX CHEMISTRY

KW - CELLULAR-DNA

KW - DAMAGE

KW - SPECTROSCOPY

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