Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution

O. B. Morozova; N. N. Fishman; A. V. Yurkovskaya

doi:10.1039/c7cp03797j

Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution

O. B. Morozova, N. N. Fishman, A. V. Yurkovskaya

Лаборатория магнитного резонанса в химии, биологии и медицине ФЕН

Результат исследования: Научные публикации в периодических изданиях › статья

5 Цитирования (Scopus)

Аннотация

By using the time-resolved chemically induced dynamic nuclear polarization technique, we show that the neutral guanosyl radical, G(-H), formed in the reaction of guanosine-5′-monophosphate with a triplet-excited 3,3′,4,4′-tetracarboxy benzophenone in neutral aqueous solution, protonates readily at the N7 position with the formation of a new guanosyl cation radical (G⁺)'.

Язык оригинала	английский
Страницы (с-по)	21262-21266
Число страниц	5
Журнал	Physical Chemistry Chemical Physics
Том	19
Номер выпуска	32
DOI	https://doi.org/10.1039/c7cp03797j
Состояние	Опубликовано - 28 авг 2017

Доступ к документу

10.1039/c7cp03797j

Link to publication in Scopus

Fingerprint Подробные сведения о темах исследования «Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать

Morozova, O. B., Fishman, N. N., & Yurkovskaya, A. V. (2017). Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution. Physical Chemistry Chemical Physics, 19(32), 21262-21266. https://doi.org/10.1039/c7cp03797j

@article{2c009bf4a891489b9012dc684c04b7ce,

title = "Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution",

abstract = "By using the time-resolved chemically induced dynamic nuclear polarization technique, we show that the neutral guanosyl radical, G(-H), formed in the reaction of guanosine-5′-monophosphate with a triplet-excited 3,3′,4,4′-tetracarboxy benzophenone in neutral aqueous solution, protonates readily at the N7 position with the formation of a new guanosyl cation radical (G+)'.",

keywords = "ELECTRON-REDUCTION POTENTIALS, TIME-RESOLVED CIDNP, GUANINE OXIDATION, PULSE-RADIOLYSIS, REDOX CHEMISTRY, CELLULAR-DNA, DAMAGE, SPECTROSCOPY, NUCLEOTIDES, CATIONS",

author = "Morozova, {O. B.} and Fishman, {N. N.} and Yurkovskaya, {A. V.}",

year = "2017",

month = aug,

day = "28",

doi = "10.1039/c7cp03797j",

language = "English",

volume = "19",

pages = "21262--21266",

journal = "Physical Chemistry Chemical Physics",

issn = "1463-9076",

publisher = "Royal Society of Chemistry",

number = "32",

}

Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution. / Morozova, O. B.; Fishman, N. N.; Yurkovskaya, A. V.

В: Physical Chemistry Chemical Physics, Том 19, № 32, 28.08.2017, стр. 21262-21266.

Результат исследования: Научные публикации в периодических изданиях › статья

TY - JOUR

T1 - Indirect NMR detection of transient guanosyl radical protonation in neutral aqueous solution

AU - Morozova, O. B.

AU - Fishman, N. N.

AU - Yurkovskaya, A. V.

PY - 2017/8/28

Y1 - 2017/8/28

N2 - By using the time-resolved chemically induced dynamic nuclear polarization technique, we show that the neutral guanosyl radical, G(-H), formed in the reaction of guanosine-5′-monophosphate with a triplet-excited 3,3′,4,4′-tetracarboxy benzophenone in neutral aqueous solution, protonates readily at the N7 position with the formation of a new guanosyl cation radical (G+)'.

AB - By using the time-resolved chemically induced dynamic nuclear polarization technique, we show that the neutral guanosyl radical, G(-H), formed in the reaction of guanosine-5′-monophosphate with a triplet-excited 3,3′,4,4′-tetracarboxy benzophenone in neutral aqueous solution, protonates readily at the N7 position with the formation of a new guanosyl cation radical (G+)'.

KW - ELECTRON-REDUCTION POTENTIALS

KW - TIME-RESOLVED CIDNP

KW - GUANINE OXIDATION

KW - PULSE-RADIOLYSIS

KW - REDOX CHEMISTRY

KW - CELLULAR-DNA

KW - DAMAGE

KW - SPECTROSCOPY

KW - NUCLEOTIDES

KW - CATIONS

UR - http://www.scopus.com/inward/record.url?scp=85027885790&partnerID=8YFLogxK

U2 - 10.1039/c7cp03797j

DO - 10.1039/c7cp03797j

M3 - Article

AN - SCOPUS:85027885790

VL - 19

SP - 21262

EP - 21266

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

SN - 1463-9076

IS - 32

ER -