Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

T. O. Abramova, M. A. Ryazanova, E. V. Antonov, O. E. Redina, A. L. Markel

Результат исследования: Научные публикации в периодических изданияхстатья

3 Цитирования (Scopus)

Аннотация

The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.

Язык оригиналаанглийский
Страницы (с-по)442-446
Число страниц5
ЖурналMolekuliarnaia biologiia
Том51
Номер выпуска3
DOI
СостояниеОпубликовано - 1 мая 2017

Ключевые слова

  • Animals
  • Blood Pressure
  • Disease Models, Animal
  • Epoxide Hydrolases/biosynthesis
  • Humans
  • Hypertension/enzymology
  • Kidney Medulla/enzymology
  • Male
  • Nitric Oxide Synthase/genetics
  • Nitrogen Oxides/metabolism
  • Oxidative Stress/genetics
  • Rats
  • Stress, Physiological/genetics

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