Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

T. O. Abramova; M. A. Ryazanova; E. V. Antonov; O. E. Redina; A. L. Markel

doi:10.7868/S0026898417020021

Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

T. O. Abramova, M. A. Ryazanova, E. V. Antonov, O. E. Redina, A. L. Markel

Кафедра физиологии ФЕН

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

3 Цитирования (Scopus)

Аннотация

The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.

Язык оригинала	английский
Страницы (с-по)	442-446
Число страниц	5
Журнал	Molekuliarnaia biologiia
Том	51
Номер выпуска	3
DOI	https://doi.org/10.7868/S0026898417020021
Состояние	Опубликовано - 1 мая 2017

Ключевые слова

Animals
Blood Pressure
Disease Models, Animal
Epoxide Hydrolases/biosynthesis
Humans
Hypertension/enzymology
Kidney Medulla/enzymology
Male
Nitric Oxide Synthase/genetics
Nitrogen Oxides/metabolism
Oxidative Stress/genetics
Rats
Stress, Physiological/genetics

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10.7868/S0026898417020021

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title = "Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension",

abstract = "The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.",

keywords = "arterial hypertension, ELISA, ISIAH rat strain, real time PCR, renal medulla, soluble epoxide hydrolase, Animals, Blood Pressure, Disease Models, Animal, Epoxide Hydrolases/biosynthesis, Humans, Hypertension/enzymology, Kidney Medulla/enzymology, Male, Nitric Oxide Synthase/genetics, Nitrogen Oxides/metabolism, Oxidative Stress/genetics, Rats, Stress, Physiological/genetics",

author = "Abramova, {T. O.} and Ryazanova, {M. A.} and Antonov, {E. V.} and Redina, {O. E.} and Markel, {A. L.}",

year = "2017",

month = may,

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doi = "10.7868/S0026898417020021",

language = "English",

volume = "51",

pages = "442--446",

journal = "Molekulyarnaya Biologiya",

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publisher = "Russian Academy of Sciences",

number = "3",

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Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension. / Abramova, T. O.; Ryazanova, M. A.; Antonov, E. V.; Redina, O. E.; Markel, A. L.

В: Molekuliarnaia biologiia, Том 51, № 3, 01.05.2017, стр. 442-446.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension

AU - Abramova, T. O.

AU - Ryazanova, M. A.

AU - Antonov, E. V.

AU - Redina, O. E.

AU - Markel, A. L.

PY - 2017/5/1

Y1 - 2017/5/1

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KW - arterial hypertension

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KW - Disease Models, Animal

KW - Epoxide Hydrolases/biosynthesis

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KW - Kidney Medulla/enzymology

KW - Male

KW - Nitric Oxide Synthase/genetics

KW - Nitrogen Oxides/metabolism

KW - Oxidative Stress/genetics

KW - Rats

KW - Stress, Physiological/genetics

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