Аннотация
The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.
| Язык оригинала | английский |
|---|---|
| Страницы (с-по) | 442-446 |
| Число страниц | 5 |
| Журнал | Molekuliarnaia biologiia |
| Том | 51 |
| Номер выпуска | 3 |
| DOI | |
| Состояние | Опубликовано - 1 мая 2017 |
Ключевые слова
- Animals
- Blood Pressure
- Disease Models, Animal
- Epoxide Hydrolases/biosynthesis
- Humans
- Hypertension/enzymology
- Kidney Medulla/enzymology
- Male
- Nitric Oxide Synthase/genetics
- Nitrogen Oxides/metabolism
- Oxidative Stress/genetics
- Rats
- Stress, Physiological/genetics
Fingerprint Подробные сведения о темах исследования «Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension». Вместе они формируют уникальный семантический отпечаток (fingerprint).
Цитировать
Abramova, T. O., Ryazanova, M. A., Antonov, E. V., Redina, O. E., & Markel, A. L. (2017). Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension. Molekuliarnaia biologiia, 51(3), 442-446. https://doi.org/10.7868/S0026898417020021