In vitro BNCT mediated boronophenylalanine evaluation on melanoma and glioma cells

Владимир Владимирович Каныгин, Анна Исмагиловна Касатова, Александр Иванович Кичигин, Евгений Леонидович Завьялов, Иван Алексеевич Разумов, Сергей Юрьевич Таскаев

Результат исследования: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаярецензирование

Аннотация

To identify the dependence of the efficiency of boron neutron capture therapy on glioma U251 and melanoma SK-Mel28 cell lines neutron irradiation in presence of 10B at the accelerator based epithermal neutron source at Budker Institute of Nuclear Physics was conducted. Cells were incubated with different concentrations of 10B labeled boronophenylalanine to the growth medium for 24 hours. The samples were placed in polymethyl methacrylate phantom on a depth of 36 mm under the neutron-generating target with following irradiation of the cells by neutron flux. Colony forming assay was performed to evaluate clonogenic capabilities of irradiated glioma and melanoma cells. I t showed that 10B increased by irradiation with neutron beam, leads to decrease in cell survival. It showed that the cells surviving decreased with increasing of 10B after irradiation with neutron beam. Concentrations of 10B in U251 and SK-Mel28 cells were detected with atomic emission spectrometer ICPE-9820 (Shimadzu, Japan) that of confirm the dependence of boron accumulation and cell death. The report presents and discusses the results of this investigation.
Язык оригиналаанглийский
Название основной публикации19th International Congress on Neutron Capture Therapy Granada, Spain, September 27th - October 1st, 2021. Book of Abstacts
Место публикацииВена
ИздательInternational Atomic Energy Agency
Страницы179
Число страниц1
СостояниеОпубликовано - 2021

Предметные области OECD FOS+WOS

  • 2.02.IQ ИНЖЕНЕРИЯ, ЭЛЕКТРИЧЕСКАЯ И ЭЛЕКТРОННАЯ

ГРНТИ

  • 47.31 Ускорители заряженных частиц и плазмы

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