Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis

Samantha Brown, Thomas Higham, Viviane Slon, Svante Paabo, Matthias Meyer, Katerina Douka, Fiona Brock, Daniel Comeskey, Noemi Procopio, Michael Shunkov, Anatoly Derevianko, Michael Buckley

Результат исследования: Научные публикации в периодических изданияхстатья

54 Цитирования (Scopus)

Аннотация

DNA sequencing has revolutionised our understanding of archaic humans during the Middle and Upper Palaeolithic. Unfortunately, while many Palaeolithic sites contain large numbers of bones, the majority of these lack the diagnostic features necessary for traditional morphological identification. As a result the recovery of Pleistocene-age human remains is extremely rare. To circumvent this problem we have applied a method of collagen fingerprinting to more than 2000 fragmented bones from the site of Denisova Cave, Russia, in order to facilitate the discovery of human remains. As a result of our analysis a single hominin bone (Denisova 11) was identified, supported through in-depth peptide sequencing analysis, and found to carry mitochondrial DNA of the Neandertal type. Subsequent radiocarbon dating revealed the bone to be > 50,000 years old. Here we demonstrate the huge potential collagen fingerprinting has for identifying hominin remains in highly fragmentary archaeological assemblages, improving the resources available for wider studies into human evolution.

Язык оригиналаанглийский
Номер статьи23559
ЖурналScientific Reports
Том6
DOI
СостояниеОпубликовано - 29 мар 2016
Опубликовано для внешнего пользованияДа

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  • Цитировать

    Brown, S., Higham, T., Slon, V., Paabo, S., Meyer, M., Douka, K., Brock, F., Comeskey, D., Procopio, N., Shunkov, M., Derevianko, A., & Buckley, M. (2016). Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis. Scientific Reports, 6, [23559]. https://doi.org/10.1038/srep23559