The results of studying the features of the hydrogeological structure and chemical and isotope composition of thermal waters from the central part of Vietnam that are characterized by intense manifestations of intrusive magmatism are presented. It is established that low–and high–thermal waters with temperature varying within 30–85°C are developed in the area under study. The value of total mineralization of the hydrotherms ranges from 0.05 to 10.05 g/dm3. It is assumed that the circulation of thermal waters that are different in temperature and chemical composition occurs at two levels. The regular change of the hydrotherm composition in the direction from mineralized chloride sodium, including with increased Ca content, to fresh sodium bicarbonate is revealed. The ratio of δ18O–δ2H isotopes indicates that the water component is based on meteoric water. In the coastal areas, there is an isotope shift towards the ocean waters, which is also confirmed by the hydrogeochemical data. The key factors for forming the chemical composition of the thermal waters in South Trungbo are their genetic type, the interaction processes in the “water–rock–gas–organic substance” system, and their equilibrium–nonequilibrium state.