Highly potent activity of isopulegol-derived substituted octahydro-2H-chromen-4-ols against influenza A and B viruses

Irina V. Ilyina, Vladimir V. Zarubaev, Irina N. Lavrentieva, Anna A. Shtro, Iana L. Esaulkova, Dina V. Korchagina, Sophia S. Borisevich, Konstantin P. Volcho, Nariman F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданияхстатья

13 Цитирования (Scopus)

Аннотация

A set of (−)-isopulegol derived octahydro-2H-chromen-4-ols was synthesized and evaluated in vitro for antiviral activity against panel of reference influenza virus strains differing in subtype, origin (human or avian) and drug resistance. Compound (4R)-11a produced via one-pot synthesis by interaction between (−)-isopulegol and acetone was found to exhibit an outstanding activity against a number of H1N1 and H2N2 influenza virus strains with selectivity index more than 1500. (4R)-11a was shown to be most potent at early stages of viral cycle. Good correlation between anti-viral activity and calculated binding energy to hemagglutinin TBHQ active site was demonstrated.

Язык оригиналаанглийский
Страницы (с-по)2061-2067
Число страниц7
ЖурналBioorganic and Medicinal Chemistry Letters
Том28
Номер выпуска11
DOI
СостояниеОпубликовано - 15 июн 2018

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